In vitro investigation on cytotoxic activity of TS4PP [5,10,15,20-tetra (4-sulfophenyl) porphyrin]

R. Alexandrova; Rodica-Mariana Ion; Elena V. Stoykova; Stanislav Shurulinkov

doi:10.1117/12.519586

4 November 2003 In vitro investigation on cytotoxic activity of TS₄PP [5,10,15,20-tetra (4-sulfophenyl) porphyrin]

R. Alexandrova, Rodica-Mariana Ion, Elena V. Stoykova, Stanislav Shurulinkov

Proceedings Volume 5226, 12th International School on Quantum Electronics: Laser Physics and Applications; (2003) https://doi.org/10.1117/12.519586
Event: 12th International School on Quantum Electronics Laser Physics and Applications, 2002, Varna, Bulgaria

Abstract

Photodynamic therapy (PDT) is a treatment modality that uses a drug and light to kill tumor cells. A large number of photosensitizing agents have been tested in PDT exeperiments. The aim of the present study was to evaluate an effect of 5, 10, 15, 20-tetra (4-sulfophenyl) porphyrin (TS₄PP) on viability of tumor (LSR-SF-SR, LSCC-SF-Mc29) and non-tumor (EBTr, L929) cell lines in vitro. The experiments were performed using neutral red uptake cytotoxicity test. Different concentrations -- 10, 100, 250 and 500 μg/ml, were tested. Light at 514 nm was applied using Ar-ion laser. The light doses delivered varied from 0.2 up to 2 J/cm². The effect of the compound without irradiation was also examined.

Citation Download Citation

R. Alexandrova, Rodica-Mariana Ion, Elena V. Stoykova, and Stanislav Shurulinkov "In vitro investigation on cytotoxic activity of TS₄PP [5,10,15,20-tetra (4-sulfophenyl) porphyrin]", Proc. SPIE 5226, 12th International School on Quantum Electronics: Laser Physics and Applications, (4 November 2003); https://doi.org/10.1117/12.519586

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