Fluorescent imaging the characteristic of Pyro-2DG uptake in the normal tissue using the Cryo-Imager

Zhihong Zhang; Dana Blessington; Gang Zheng; Qingming Luo; Britton Chance

doi:10.1117/12.546193

8 December 2003 Fluorescent imaging the characteristic of Pyro-2DG uptake in the normal tissue using the Cryo-Imager

Zhihong Zhang, Dana Blessington, Gang Zheng, Qingming Luo, Britton Chance

Proceedings Volume 5254, Third International Conference on Photonics and Imaging in Biology and Medicine; (2003) https://doi.org/10.1117/12.546193
Event: Third International Conference on Photonics and Imaging in Biology and Medicine, 2003, Wuhan, China

Abstract

In the previous study, we have proved that Pyro-2DG could be trapped and accumulated in the tumor. The fluorescent signal of Pyro-2DG has high correlation with the redox ratio. To further study the extrinsic probe Pyro-2DG, the characteristic of Pyro-2DG uptake by the liver tissue of rats and the distribution of Pyro-2DG in various tissues were detected using the Cryo-Imager. The result indicated that Pyro-2DG uptake by the liver resulted in the metabolic state shift towards an increased concentration of oxidized electron carriers and it completely recovered after 24hrs. Pyro-2DG with infusion injection could avoid the oxidized damage of the normal tissue induced by Pyro-2DG uptake. The distribution of Pyro-2DG in various normal tissues indicated that Pyro-2DG could be as a tumor special near infrared ray (NIR) probe besides the hepatic tumor and lymph system tumor.

Citation Download Citation

Zhihong Zhang, Dana Blessington, Gang Zheng, Qingming Luo, and Britton Chance "Fluorescent imaging the characteristic of Pyro-2DG uptake in the normal tissue using the Cryo-Imager", Proc. SPIE 5254, Third International Conference on Photonics and Imaging in Biology and Medicine, (8 December 2003); https://doi.org/10.1117/12.546193

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