Optical intrinsic signals in rat primary somatosensory cortex during non-noxious and noxious electrical stimulation of the sciatic nerve

Weihua Luo; Pengcheng Li; Shangbin Chen; Qingming Luo

doi:10.1117/12.546230

8 December 2003 Optical intrinsic signals in rat primary somatosensory cortex during non-noxious and noxious elecrical stimulation of the sciatic nerve

Weihua Luo, Pengcheng Li, Shangbin Chen, Qingming Luo

Author Affiliations +

Proceedings Volume 5254, Third International Conference on Photonics and Imaging in Biology and Medicine; (2003) https://doi.org/10.1117/12.546230
Event: Third International Conference on Photonics and Imaging in Biology and Medicine, 2003, Wuhan, China

Abstract

Optical imaging method was applied into observing the temporal-spatial characteristic of rat primary somatosensory cortex during graded electrical stimulation of the sciatic nerve (5hz,duration of 2s,0.5ms puls,1x,10x and 20x muscle twitch threshold). We found that the temporal and spatial properties of hindlimb somatosensory cortex were modulated by graded intensity electrical stimulation of the sciatic nerve. The magnitude and time course were larger and longer with the intensity raising. And the spatial extent was wider at 20x stimulus than the other two kinds of stimulus. Therefore, our optical imaging was based on 570nm, which only reflect the changes of blood volume. Then our future study will reveal more information of pain modulation in primary somatosensory cortex.

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Weihua Luo, Pengcheng Li, Shangbin Chen, and Qingming Luo "Optical intrinsic signals in rat primary somatosensory cortex during non-noxious and noxious elecrical stimulation of the sciatic nerve", Proc. SPIE 5254, Third International Conference on Photonics and Imaging in Biology and Medicine, (8 December 2003); https://doi.org/10.1117/12.546230

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KEYWORDS

Nerve

Somatosensory cortex

Optical imaging

Silicon

Blood

Modulation

Reflectivity

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