The effects of low-intensity laser irradiation on the fatigue induced by dysfunction of mitochondria

Xiao-Yang Xu; Timon Cheng-Yi Liu; Rui Duan; Xiao-Guang Liu

doi:10.1117/12.546132

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8 December 2003 The effects of low-intensity laser irradiation on the fatigue induced by dysfunction of mitochondria

Xiao-Yang Xu, Timon Cheng-Yi Liu, Rui Duan, Xiao-Guang Liu

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Proceedings Volume 5254, Third International Conference on Photonics and Imaging in Biology and Medicine; (2003) https://doi.org/10.1117/12.546132
Event: Third International Conference on Photonics and Imaging in Biology and Medicine, 2003, Wuhan, China

Abstract

Exercise-induced fatigue has long been an important field in sports medicine. The electron leak of mitochondrial respiratory chain during the ATP synthesis integrated with proton leak and O^-.2can decrease the efficiency of ATP synthesis in mitochondria. And the exercise-induced fatigue occur followed by the decrease of performance. If the dysfunction of mitochondria can be avoided, the fatigue during the exercise may be delayed and the performance may be enhanced. Indeed there are some kind of materials can partially prevent the decrease of ATP synthesis efficiency in mitochondria. But the side effects and safety of these materials is still needed to be studied. Low intensity laser can improve the mitochondria function. It is reasonable to consider that low intensity laser therapy may become the new and more effective way to delay or elimination the fatigue induced by dysfunction of mitochondria. Because the effect of laser irradiation may not be controlled exactly when study in vivo, we use electrical stimulation of C2C12 muscle cells in culture to define the effect of low intensity laser on the dysfunction of mitochondria, and to define the optimal laser intensity to prevent the decrease of ATP synthesis efficiency. Our study use the C2C12 muscle cells in culture to define some of the mechanisms involved in the contractile-induced changes of mitochondrial function firstly in sports medicine and may suggest a useful study way to other researchers. We also give a new way to delay or eliminating the fatigue induced by dysfunction of mitochondria without side effect.

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Xiao-Yang Xu, Timon Cheng-Yi Liu, Rui Duan, and Xiao-Guang Liu "The effects of low-intensity laser irradiation on the fatigue induced by dysfunction of mitochondria", Proc. SPIE 5254, Third International Conference on Photonics and Imaging in Biology and Medicine, (8 December 2003); https://doi.org/10.1117/12.546132

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