A fiber optic approach for in vivo minimally invasive study of tissue optical properties

Ilko K. Ilev; Ronald W Waynant; Kimberly R Byrnes; Juanita Anders

doi:10.1117/12.529159

10 June 2004 A fiber optic approach for in vivo minimally invasive study of tissue optical properties

Ilko K. Ilev, Ronald W Waynant, Kimberly R Byrnes, Juanita Anders

Proceedings Volume 5317, Optical Fibers and Sensors for Medical Applications IV; (2004) https://doi.org/10.1117/12.529159
Event: Biomedical Optics 2004, 2004, San Jose, CA, United States

Abstract

Based on a fiber-optic approach, we present a fundamental in vivo study of optical properties and light transmission characteristics of single and multiple tissue layers and blood in a Sprague Dawley rat model. In our experiments, we utilize either coherent laser sources with various energy and spectral characteristics or incoherent light sources in a broadband spectral range covering the visible and near-infrared (from 400 nm to 1200 nm). The measurement techniques are based on a simple minimally invasive fiber-optic light delivery system that provides an effective method for homogeneously and precisely controlling the light irradiation of the tissue medium as well as being a highly sensitive detector of the tissue's scattered light. The delivery-sensor probes are placed into different tissue layers (skin, sub-cutaneous connective and deep connective tissue, back muscle, bone and spinal cord) and blood, and broadband spectral transmission characteristics of these media are measured in vivo. The transmission spectra are analyzed in order to determine the specificity of interaction of different tissues with light. The main goal is to determine the most effective coherent or incoherent light sources and their optimal parameters that might be used for minimally invasive therapeutic and optical diagnostics techniques.

Citation Download Citation

Ilko K. Ilev, Ronald W Waynant, Kimberly R Byrnes, and Juanita Anders "A fiber optic approach for in vivo minimally invasive study of tissue optical properties", Proc. SPIE 5317, Optical Fibers and Sensors for Medical Applications IV, (10 June 2004); https://doi.org/10.1117/12.529159

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available