Measurement of refractive index variation of physiological analytes using differential-phase OCT

Kirill V. Larin; Taner Akkin; Thomas E. Milner; Digand P. Dave; Massoud Motamedi; Rinat O. Esenaliev

doi:10.1117/12.532004

18 June 2004 Measurement of refractive index variation of physiological analytes using differential-phase OCT

Kirill V. Larin, Taner Akkin, Thomas E. Milner, Digand P. Dave, Massoud Motamedi, Rinat O. Esenaliev

Proceedings Volume 5325, Optical Diagnostics and Sensing IV; (2004) https://doi.org/10.1117/12.532004
Event: Biomedical Optics 2004, 2004, San Jose, CA, United States

Abstract

We report results of a study using differential phase optical coherence tomography (DP-OCT) for measurement of variation of refractive index (n) vs. analyte concentration (C) in translucent solutions and turbid tissue phantoms. Variation of refractive index with analyte concentration (dn/dC) in aqueous solutions of glucose, calcium chloride, magnesium chloride, sodium chloride, potassium chloride, potassium bicarbonate, urea, bovine serum albumin, and bovine globulin was measured. Obtained results demonstrated: (1) dn/dC for glucose is significantly greater than that of other analytes in the physiological range; and (2) high sensitivity of DP-OCT method for measurement of analyte concentration.

Citation Download Citation

Kirill V. Larin, Taner Akkin, Thomas E. Milner, Digand P. Dave, Massoud Motamedi, and Rinat O. Esenaliev "Measurement of refractive index variation of physiological analytes using differential-phase OCT", Proc. SPIE 5325, Optical Diagnostics and Sensing IV, (18 June 2004); https://doi.org/10.1117/12.532004

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