Optical biosensor based on localized surface plasmon resonance with high spatial resolution

Xin Hong; Fu-Jen Kao

doi:10.1117/12.525962

16 June 2004 Optical biosensor based on localized surface plasmon resonance with high spatial resolution

Xin Hong, Fu-Jen Kao

Proceedings Volume 5327, Plasmonics in Biology and Medicine; (2004) https://doi.org/10.1117/12.525962
Event: Biomedical Optics 2004, 2004, San Jose, CA, United States

Abstract

We are using a gold nanoparticle coated film to achieve high spatially resolved biosensing that is based on localized surface plasmon resonance (LSPR). This special film possesses the unique optical properties of being not sensitive to the changes of incident angle and relies exclusively on the spectral shift of absorption peak for biosensing. This uniqueness enables it to be compatible with high numerical aperture (NA) optics and to achieve high spatial resolution. We demonstrate a spatial resolution of 25μm assuming a maximum of spectral fluctuation of 0.1nm is acceptable.

Citation Download Citation

Xin Hong and Fu-Jen Kao "Optical biosensor based on localized surface plasmon resonance with high spatial resolution", Proc. SPIE 5327, Plasmonics in Biology and Medicine, (16 June 2004); https://doi.org/10.1117/12.525962

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