Optical biosensors based on four different surface plasmon resonance modes: sensitivity comparison

Fan-Ching Chien; Shean-Jen Chen

doi:10.1117/12.530434

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16 June 2004 Optical biosensors based on four different surface plasmon resonance modes: sensitivity comparison

Fan-Ching Chien, Shean-Jen Chen

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Proceedings Volume 5327, Plasmonics in Biology and Medicine; (2004) https://doi.org/10.1117/12.530434
Event: Biomedical Optics 2004, 2004, San Jose, CA, United States

Abstract

Current surface plasmon resonance (SPR) modes based on the attenuated total reflection (ATR) method can broadly be categorized as: conventional SPR, long-range SPR (LRSPR), coupled plasmon-waveguide resonance (CPWR), and waveguide-coupled SPR (WCSPR). Although the features of optical biosensors are dependent upon their particular SPR mode, a common requirement for all biosensors utilized for biomolecular interaction analysis (BIA) is a high degree of sensitivity. The current paper presents a theoretical analysis and comparison of the sensitivity and resolution of these four types of SPR biosensors when employed in three of the most prevalent detection methods, namely angular interrogation, wavelength interrogation, and intensity measurement. This study develops a detailed understanding of the influences of various biosensor design parameters in order to enhance the sensitivity and detection limit capabilities of such devices.

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Fan-Ching Chien and Shean-Jen Chen "Optical biosensors based on four different surface plasmon resonance modes: sensitivity comparison", Proc. SPIE 5327, Plasmonics in Biology and Medicine, (16 June 2004); https://doi.org/10.1117/12.530434

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