NIR optical probes targeting glucose transporters

Hui Li; Juan Chen; Min Zhang; Zhihong Zhang; David Benaron; Britton Chance; Jerry D. Glickson; Gang Zheng

doi:10.1117/12.533148

14 June 2004 NIR optical probes targeting glucose transporters

Hui Li, Juan Chen, Min Zhang, Zhihong Zhang, David Benaron, Britton Chance, Jerry D. Glickson, Gang Zheng

Proceedings Volume 5329, Genetically Engineered and Optical Probes for Biomedical Applications II; (2004) https://doi.org/10.1117/12.533148
Event: Biomedical Optics 2004, 2004, San Jose, CA, United States

Abstract

A current limitation of NIR imaging is the lack of sufficient tumor-to-tissue contrast due to the nonspecific nature of delivering the dye to the tumor. Utilizing one of the most important cancer signatures, the overexpression of GLUTs, we have developed a series of 2-deoxyglucose conjugated NIR dyes (NIR- 2DG) to enhance tumor selectivity. This uptake mechanism is first confirmed in vitro by confocal microscopy and flow cytometry studies with various cancer cells. Following intravenously administration to animals, NIR-2DGs are selectively accumulated in the tumor compared to the surrounding normal tissue as observed by ex vivo and in vivo fluorescence imaging techniques.

Citation Download Citation

Hui Li, Juan Chen, Min Zhang, Zhihong Zhang, David Benaron, Britton Chance, Jerry D. Glickson, and Gang Zheng "NIR optical probes targeting glucose transporters", Proc. SPIE 5329, Genetically Engineered and Optical Probes for Biomedical Applications II, (14 June 2004); https://doi.org/10.1117/12.533148

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