Targeting the expression of integrin receptors in tumors

Sharon Bloch; Kexian Liang; Richard B. Dorshow; Yunpeng Ye; Samuel I. Achilefu

doi:10.1117/12.533160

14 June 2004 Targeting the expression of integrin receptors in tumors

Sharon Bloch, Kexian Liang, Richard B. Dorshow, Yunpeng Ye, Samuel I. Achilefu

Proceedings Volume 5329, Genetically Engineered and Optical Probes for Biomedical Applications II; (2004) https://doi.org/10.1117/12.533160
Event: Biomedical Optics 2004, 2004, San Jose, CA, United States

Abstract

Expression of integrin αvβ3 is upregulated in a number of cancers including colon, pancreas, lung and breast. Additionally, αvβ3 integrin expression has been linked to tumor metastasis and targeting this cell surface protein could provide a viable approach to image and evaluate the metastatic potential of tumors. Accordingly, we evaluated the selective retention of some near infrared (NIR) fluorescent probes in nude mice bearing A549 lung cancer xenograft that express αvβ3 integrin. Our preliminary results indicate that a novel NIR probe designed to target this integrin selectively accumulated in A549 tumor while other non-integrin specific probes were not retained in the tumor. Blocking studies show that tumor uptake of the probe is mediated by αvβ3 integrin receptor.

Citation Download Citation

Sharon Bloch, Kexian Liang, Richard B. Dorshow, Yunpeng Ye, and Samuel I. Achilefu "Targeting the expression of integrin receptors in tumors", Proc. SPIE 5329, Genetically Engineered and Optical Probes for Biomedical Applications II, (14 June 2004); https://doi.org/10.1117/12.533160

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