Novel multifunctional near-infrared fluorescent nanoparticles: integrating nanotechnology and biophotonics

Vishal Saxena; Mostafa Sadoqi; S. Kumar; Jun Shao

doi:10.1117/12.534329

1 June 2004 Novel multifunctional near-infrared fluorescent nanoparticles: integrating nanotechnology and biophotonics

Vishal Saxena, Mostafa Sadoqi, S. Kumar, Jun Shao

Proceedings Volume 5331, Nanobiophotonics and Biomedical Applications; (2004) https://doi.org/10.1117/12.534329
Event: Biomedical Optics 2004, 2004, San Jose, CA, United States

Abstract

The objective of this study is to engineer a novel nanoparticlulate system for use in early tumor diagnosis. Indocyanine green (ICG)-loaded biodegradable nanoparticles were prepared by using biodegradable polymer, poly(DL-lactic-co-glycolic acid) (PLGA). The ICG entrapment, nanoparticle size, shape, zeta potential the release of ICG from nanoparticles was determined. Also, the effect of ICG entrapment on fluorescence spectra of ICG was measured. The engineered nanoparticles were nearly spherical in shape and efficiently entrapped ICG. The release profile of the nanoparticles was exponential. The entrapment of ICG in nanoparticles caused reduction in its peak fluorescence intensity and shifted its wavelength of peak fluorescence to higher values.

Citation Download Citation

Vishal Saxena, Mostafa Sadoqi, S. Kumar, and Jun Shao "Novel multifunctional near-infrared fluorescent nanoparticles: integrating nanotechnology and biophotonics", Proc. SPIE 5331, Nanobiophotonics and Biomedical Applications, (1 June 2004); https://doi.org/10.1117/12.534329

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