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1 June 2004 Photonic and magnetic nanoexplorers for biomedical use: from subcellular imaging to cancer diagnostics and therapy
Brian Ross, Alnawaz Rehemtulla, Yong-Eun Lee Koo, Ramachandra Reddy, Gwangseong Kim, Caleb Behrend, Sarah Buck, Randal J. Schneider, Martin A. Philbert, Ralph Weissleder, Raoul Kopelman
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Proceedings Volume 5331, Nanobiophotonics and Biomedical Applications; (2004) https://doi.org/10.1117/12.537653
Event: Biomedical Optics 2004, 2004, San Jose, CA, United States
Abstract
A paradigm for brain cancer detection, treatment, and monitoring uses synergistic, multifunctional, biomedical nanoparticles for: (1) external delivery to cancer cells of singlet oxygen and reactive oxygen species (ROS), but no drugs, thus avoiding multi-drug resistance, (2) photodynamic generation of singlet oxygen and ROS by a conserved critical mass of photosensitizer, (3) enhancement of magnetic relaxivity providing for MRI contrast, (4) control of plasma residence time, (5) specific cell targeting, (6) minimized toxicity, (7) measurement of tumor kill with diffusion MRI. The 40 nm polyacrylamide nanoparticles contained Photofrin, iron-oxide (or Gd), polyethylene glycol and targeting moieties. In-vivo tumor growth was halted and even reversed.
© (2004) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
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Brian Ross, Alnawaz Rehemtulla, Yong-Eun Lee Koo, Ramachandra Reddy, Gwangseong Kim, Caleb Behrend, Sarah Buck, Randal J. Schneider, Martin A. Philbert, Ralph Weissleder, and Raoul Kopelman "Photonic and magnetic nanoexplorers for biomedical use: from subcellular imaging to cancer diagnostics and therapy", Proc. SPIE 5331, Nanobiophotonics and Biomedical Applications, (1 June 2004); https://doi.org/10.1117/12.537653
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Cited by 26 scholarly publications and 3 patents.
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KEYWORDS
Nanoparticles
Tumors
Magnetic resonance imaging
Photodynamic therapy
Oxygen
Particles
Cancer
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