Visualization and quantitative analysis of lung microstructure using micro CT images

Tetsuo Yamamoto; Mitsuru Kubo; Yoshiki Kawata; Noboru Niki; Eisuke Matsui; Hironobu Ohamatsu; Noriyuki Moriyama

doi:10.1117/12.534769

30 April 2004 Visualization and quantitative analysis of lung microstructure using micro CT images

Tetsuo Yamamoto, Mitsuru Kubo, Yoshiki Kawata, Noboru Niki, Eisuke Matsui, Hironobu Ohamatsu, Noriyuki Moriyama

Proceedings Volume 5369, Medical Imaging 2004: Physiology, Function, and Structure from Medical Images; (2004) https://doi.org/10.1117/12.534769
Event: Medical Imaging 2004, 2004, San Diego, California, United States

Abstract

Micro CT system is developed for lung function analysis at a high resolution of the micrometer order (up to 5 μm in spatial resolution). This system reveals the lung distal structures such as interlobular septa, terminal bronchiole, respiratory bronchiole, alveolar duct, and alveolus. In order to visualize lung 3-D microstructures using micro CT images and to analyze them, this research presents a computerized approach. In this approach, the following things are performed: (1) extracting lung distal structures from micro CT images, (2) visualizing extracted lung microstructure in three dimensions, and (3) visualizing inside of lung distal area in three dimensions with fly-through. This approach is applied for to micro CT images of human lung tissue specimens that were obtained by surgical excision and were kept in the state of the inflated fixed lung. And this research succeeded in visualization of lung microstructures using micro CT images to reveal the lung distal structures from bronchiole up to alveolus.

Citation Download Citation

Tetsuo Yamamoto, Mitsuru Kubo, Yoshiki Kawata, Noboru Niki, Eisuke Matsui, Hironobu Ohamatsu, and Noriyuki Moriyama "Visualization and quantitative analysis of lung microstructure using micro CT images", Proc. SPIE 5369, Medical Imaging 2004: Physiology, Function, and Structure from Medical Images, (30 April 2004); https://doi.org/10.1117/12.534769

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