Reflectance and fluorescence hyperspectral elastic image registration

Holger Lange; Ross Baker; Johan Hakansson; Ulf Peter Gustafsson

doi:10.1117/12.535720

12 May 2004 Reflectance and fluorescence hyperspectral elastic image registration

Holger Lange, Ross Baker, Johan Hakansson, Ulf Peter Gustafsson

Author Affiliations +

Proceedings Volume 5370, Medical Imaging 2004: Image Processing; (2004) https://doi.org/10.1117/12.535720
Event: Medical Imaging 2004, 2004, San Diego, California, United States

Abstract

Science and Technology International (STI) presents a novel multi-modal elastic image registration approach for a new hyperspectral medical imaging modality. STI's HyperSpectral Diagnostic Imaging (HSDI) cervical instrument is used for the early detection of uterine cervical cancer. A Computer-Aided-Diagnostic (CAD) system is being developed to aid the physician with the diagnosis of pre-cancerous and cancerous tissue regions. The CAD system uses the fusion of multiple data sources to optimize its performance. The key enabling technology for the data fusion is image registration. The difficulty lies in the image registration of fluorescence and reflectance hyperspectral data due to the occurrence of soft tissue movement and the limited resemblance of these types of imagery. The presented approach is based on embedding a reflectance image in the fluorescence hyperspectral imagery. Having a reflectance image in both data sets resolves the resemblance problem and thereby enables the use of elastic image registration algorithms required to compensate for soft tissue movements. Several methods of embedding the reflectance image in the fluorescence hyperspectral imagery are described. Initial experiments with human subject data are presented where a reflectance image is embedded in the fluorescence hyperspectral imagery.

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Holger Lange, Ross Baker, Johan Hakansson, and Ulf Peter Gustafsson "Reflectance and fluorescence hyperspectral elastic image registration", Proc. SPIE 5370, Medical Imaging 2004: Image Processing, (12 May 2004); https://doi.org/10.1117/12.535720

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