Hemolysis induced by psoralen previously photo-oxidized in ethanol or aqueous solutions

Alla A. Kyagova; Mekhriban I. Ismailova; Mikhail V. Malakhov; Alexander Ya. Potapenko

doi:10.1117/12.578949

20 August 2004 Hemolysis induced by psoralen previously photo-oxidized in ethanol or aqueous solutions

Alla A. Kyagova, Mekhriban I. Ismailova, Mikhail V. Malakhov, Alexander Ya. Potapenko

Proceedings Volume 5474, Saratov Fall Meeting 2003: Optical Technologies in Biophysics and Medicine V; (2004) https://doi.org/10.1117/12.578949
Event: Saratov Fall Meeting 2003, 2003, Saratov, Russian Federation

Abstract

Hemolytic effects of psoralen previously photooxidized (366 nm) in ethanol and aqueous solutions were investigated on human erythrocytes. Photooxidation of psoralen in ethanol or aqueous solutions gives a mixture of hemolysins, some of which spontaneously degrade during about 0.5 h of storage with a loss of hemolytic activity whilst others retain their activity during several days of storage. On exposure of psoralen to UVA irradiation in ethanol solutions, water-degradable hemolysins along with not degradable by water are produced. Reciprocity law of the fluence rate and time of irradiation is not fulfilled for the hemolysins production; they are more efficiently produced at high fluence rate of ultraviolet.

Citation Download Citation

Alla A. Kyagova, Mekhriban I. Ismailova, Mikhail V. Malakhov, and Alexander Ya. Potapenko "Hemolysis induced by psoralen previously photo-oxidized in ethanol or aqueous solutions", Proc. SPIE 5474, Saratov Fall Meeting 2003: Optical Technologies in Biophysics and Medicine V, (20 August 2004); https://doi.org/10.1117/12.578949

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