Optical coherence tomography: potentialities in clinical practice

Elena Zagaynova; Natalia D. Gladkova M.D.; Andrey Shakhov; Anna Terentjeva; Ludmila B. Snopova M.D.; Irina A. Kuznetzova M.D.; Olga Streltzova; Natalia M. Shakhova M.D.; Vladislav A. Kamensky; Grigory V. Gelikonov; Valentin M. Gelikonov; Roman V. Kuranov; Alex Myakov

doi:10.1117/12.580771

20 August 2004 Optical coherence tomography: potentialities in clinical practice

Elena Zagaynova, Natalia D. Gladkova M.D., Andrey Shakhov, Anna Terentjeva, Ludmila B. Snopova M.D., Irina A. Kuznetzova M.D., Olga Streltzova, Natalia M. Shakhova M.D., Vladislav A. Kamensky, Grigory V. Gelikonov, Valentin M. Gelikonov, Roman V. Kuranov, Alex Myakov

Author Affiliations +

Proceedings Volume 5474, Saratov Fall Meeting 2003: Optical Technologies in Biophysics and Medicine V; (2004) https://doi.org/10.1117/12.580771
Event: Saratov Fall Meeting 2003, 2003, Saratov, Russian Federation

Abstract

Clinical studies using OCT involved 2000 patients in various fields of medicine such as gastroenterology, urology, laryngology, gynecology, dermatology, stomatology, etc. Layered high-contrast images were typical for benign epithelial conditions. OCT distinguish in mucosae: epithelium, connective tissue layer, and smooth-muscle layer. Various benign processes occurring in mucosa manifest in OCT images as changes in the epithelial height, scattering properties and the course of the basement membrane. Lack of the layered structural pattern is the main criterion for dysplastic / malignant images. In clinic: OCT data may be critical for choosing a tissue site for excisional biopsy, OCT can detect tumor borders and their linear dimensions, OCT can be used to plan a resection line in operations and to control adequacy of resection, to monitor whether reparative processes are timely and adequate. OCT sensitivity of the uterine cervix, urinary bladder and larynx is 82, 98, 77%, respectively, specificity - 78, 71, 96%, diagnostic accuracy - 81, 85, 87% with significantly good agreement index of clinicians kappa - 0.65, 0.79, 0.83 (confidence intervals: 0.57-0.73; 0.71-0.88; 0.74-0.91). Error in detection of high grade dysplasia and microinvasive cancer is 21.4% in average. Additional modification of OCT (cross-polarisation OCT, OCM), development of the procedure (biotissue compression, application of chemical agents) can improve the specificity and sensitivity of traditional modality.

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Elena Zagaynova, Natalia D. Gladkova M.D., Andrey Shakhov, Anna Terentjeva, Ludmila B. Snopova M.D., Irina A. Kuznetzova M.D., Olga Streltzova, Natalia M. Shakhova M.D., Vladislav A. Kamensky, Grigory V. Gelikonov, Valentin M. Gelikonov, Roman V. Kuranov, and Alex Myakov "Optical coherence tomography: potentialities in clinical practice", Proc. SPIE 5474, Saratov Fall Meeting 2003: Optical Technologies in Biophysics and Medicine V, (20 August 2004); https://doi.org/10.1117/12.580771

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