A theoretical model on optical clearing of biological tissue with chemical active agents

Fujun Zhou; Yonghong He; Ruikang K. Wang

doi:10.1117/12.572018

29 July 2004 A theoretical model on optical clearing of biological tissue with chemical active agents

Fujun Zhou, Yonghong He, Ruikang K. Wang

Proceedings Volume 5486, ALT'03 International Conference on Advanced Laser Technologies: Biomedical Optics; (2004) https://doi.org/10.1117/12.572018
Event: ALT'03 International Conference on Advanced Laser Technologies: Biomedical Optics, 2003, Silsoe, United Kingdom

Abstract

Quantitative analysis of biological tissue responding to chemical active agents (CAA) that osmotically transport across tissues poses a challenge task for modern biomedical technologies. It is known that the application of osmotically CAA to biotissue such as skin, muscle and gastrointestinal tracts can make the biological tissue transparent. Such osmotic action of agents to the biological tissue have not yet been understood or quantified in a way that degree of optical clearing to the tissue is predictive. We consider that optical properties of biological tissue are altered due to the changes of micro-structures and scattering constituents after CAA permeates into tissue. The changes of optical properties of biological tissue are due to the refractive indices matching between the particles (scatterers) with high refractive index and the ground substances leading to reduce scattering of tissue. The main reasons are that permeated CAA with higher refractive index than the ground substances of tissue make the refractive index of ground substances of tissue higher by the enhancement of the permeated concentration. In this paper, we described a theoretical model based on the collimated transmittance changes of light penetrating fibrous tissue after the CAA administrates with different concentration.

Citation Download Citation

Fujun Zhou, Yonghong He, and Ruikang K. Wang "A theoretical model on optical clearing of biological tissue with chemical active agents", Proc. SPIE 5486, ALT'03 International Conference on Advanced Laser Technologies: Biomedical Optics, (29 July 2004); https://doi.org/10.1117/12.572018

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