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29 July 2004 Study on the effects of low-energy laser irradiation on the development of mouse S180 ascites sarcoma in vivo
Baoxu Huang, Hongbin Wang, Huanqi Liu, Zhina Qu, Xifeng Liu, Shaohui Cheng
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Proceedings Volume 5486, ALT'03 International Conference on Advanced Laser Technologies: Biomedical Optics; (2004) https://doi.org/10.1117/12.572055
Event: ALT'03 International Conference on Advanced Laser Technologies: Biomedical Optics, 2003, Silsoe, United Kingdom
Abstract
The antitumor effects of low-energy laser irradiation (LELI) are always the focus of scientific investigation. The purpose of this study was to test the effects of low-energy He-Ne laser irradiation on mouse S180 ascites sarcoma. After innoculating S180 sarcoma cells at the dosage of 1 x 106 cells per mouse, five group of BALB/c mice were irradiated at the spot of one Harder's glands of the mouse eye for six days with five different dosages of 7.33, 11.00, 14.67, 22.00 and 29.33 J/cm2 respectively. The antitumor effects were evaluated in two aspects: life prolongation ratio and ascites growth of tumor-bearing mice. The results showed that low energy He-Ne laser irradiation of 7.33, 11.00, 14.67, 22.00 and 29.33 J/cm2 could inhibit the proliferation speed of S180 ascites sarcoma in vivo, and therefore could prolong the survival time of the tumor bearing mice in some degree. Moreover, the dosage of 14.67 J/cm2 showed the most remarkable inhibiting effects among the four dosages, and the life prolongation ratio was up to 45.51%. On the contrary, the proliferation speed of S180 ascites sarcoma cells in vivo was accelerated by the large dosage of 29.33 J/cm2 LELI and the survival time of the tumor bearing mice were remarkably shortened. Low energy He-Ne laser irradiation with proper dosages can inhibit the development of the mouse S180 ascites sarcoma, while too large dosage shows promotive effects.
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Baoxu Huang, Hongbin Wang, Huanqi Liu, Zhina Qu, Xifeng Liu, and Shaohui Cheng "Study on the effects of low-energy laser irradiation on the development of mouse S180 ascites sarcoma in vivo", Proc. SPIE 5486, ALT'03 International Conference on Advanced Laser Technologies: Biomedical Optics, (29 July 2004); https://doi.org/10.1117/12.572055
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KEYWORDS
Tumors
Helium neon lasers
Laser irradiation
In vivo imaging
Medicine
Agriculture
Eye
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