Photoaggregation of crystallins (main proteins of eye lens) under the effect of XeCl laser radiation

Lev V. Soustov; Evgeny V. Chelnokov; Nikita M. Bityurin; A. L. Kiselev; V. V. Nemov; Yu. V. Sergeev; Michail A. Ostrovsky

doi:10.1117/12.579988

15 July 2004 Photoaggregation of crystallins (main proteins of eye lens) under the effect of XeCl laser radiation

Lev V. Soustov, Evgeny V. Chelnokov, Nikita M. Bityurin, A. L. Kiselev, V. V. Nemov, Yu. V. Sergeev, Michail A. Ostrovsky

Author Affiliations +

Proceedings Volume 5506, Nonresonant Laser-Matter Interaction (NLMI-11); (2004) https://doi.org/10.1117/12.579988
Event: Nonresonant Laser-Matter Interaction (NLMI-11), 2003, St. Petersburg, Russian Federation

Abstract

UV light is one of primary factors associated with cataract formation in the eye lens. α-, β-, γ-Crystallins maintain lens transparency, and damage to these proteins plays a major role in cataract formation. The effect of XeCl laser radiation (308 nm) on β_L-crystallin solution is studied. The strong dependence of protein aggregation kinetics on both laser fluence (w) and repetition rate (F) is investigated. The kinetics features are similar to those of carbonic anhydrase photoaggregation studied previously.

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Lev V. Soustov, Evgeny V. Chelnokov, Nikita M. Bityurin, A. L. Kiselev, V. V. Nemov, Yu. V. Sergeev, and Michail A. Ostrovsky "Photoaggregation of crystallins (main proteins of eye lens) under the effect of XeCl laser radiation", Proc. SPIE 5506, Nonresonant Laser-Matter Interaction (NLMI-11), (15 July 2004); https://doi.org/10.1117/12.579988

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