Pathological calcifications studied with micro-CT

Stuart R. Stock; Nalini M. Rajamannan; Ellen R. Brooks; Craig B. Langman; Lauren M. Pachman

doi:10.1117/12.560466

26 October 2004 Pathological calcifications studied with micro-CT

Stuart R. Stock, Nalini M. Rajamannan, Ellen R. Brooks, Craig B. Langman, Lauren M. Pachman

Proceedings Volume 5535, Developments in X-Ray Tomography IV; (2004) https://doi.org/10.1117/12.560466
Event: Optical Science and Technology, the SPIE 49th Annual Meeting, 2004, Denver, Colorado, United States

Abstract

The microstructure of pathological biomineral deposits has received relatively little attention, perhaps, in part because of the difficulty preparing samples for microscopy. MicroCT avoids these difficulties, and laboratory microCT results are reviewed for aortic valve calcification (human as well as a rabbit model), for human renal calculi (stones) and for calcinoses formed in juvenile dermatomyositis (JDM). In calcified aortic valves of rabbits, numerical analysis of the data shows statistically significant correlation with diet. In a large kidney stone the pattern of mineralization is clearly revealed and may provide a temporal blueprint for stone growth. In JDM calcified deposits, very different microstructures are observed and may be related to processes unique to this disease.

Citation Download Citation

Stuart R. Stock, Nalini M. Rajamannan, Ellen R. Brooks, Craig B. Langman, and Lauren M. Pachman "Pathological calcifications studied with micro-CT", Proc. SPIE 5535, Developments in X-Ray Tomography IV, (26 October 2004); https://doi.org/10.1117/12.560466

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