Qualitative optical fiber laser induced fluorescence spectroscopy for earlier cancer diagnosis

Chan Kyu Kim; Sunil K. Khijwania; Jagdish P. Singh

doi:10.1117/12.571497

14 December 2004 Qualitative optical fiber laser induced fluorescence spectroscopy for earlier cancer diagnosis

Chan Kyu Kim, Sunil K. Khijwania, Jagdish P. Singh

Proceedings Volume 5589, Fiber Optic Sensor Technology and Applications III; (2004) https://doi.org/10.1117/12.571497
Event: Optics East, 2004, Philadelphia, Pennsylvania, United States

Abstract

Laser-induced fluorescence (LIF) is an accurate, sensitive and rapid method for the diagnosis of a normal and malignant tissue. In this paper, an optical fiber sensor was developed to enhance spectral difference between the normal and malignant tissue with sensor optimization to improve the accuracy of cancer diagnosis. This instrument incorporated a pulsed laser operating at 355 nm (frequency triple Nd:YAG and Q-switched Nd:YAG pump dye laser) with bifurcated optical fiber to allow illumination of tissue and collection of fluorescence with a single fiber. Using the laser excitation, the detection of the fluorescence signal from the tissue was performed almost instantaneously. A sufficient fluorescence contrast (of the order of more than 22.22 times) for malignant versus normal tissue was obtained. The results of our approach were compared with histopathology results and indicated excellent agreement in the classification of normal and malignant tissue.

Citation Download Citation

Chan Kyu Kim, Sunil K. Khijwania, and Jagdish P. Singh "Qualitative optical fiber laser induced fluorescence spectroscopy for earlier cancer diagnosis", Proc. SPIE 5589, Fiber Optic Sensor Technology and Applications III, (14 December 2004); https://doi.org/10.1117/12.571497

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