DNA microarrays on a mesospaced surface

Bong Jin Hong; Joon Won Park

doi:10.1117/12.569677

29 December 2004 DNA microarrays on a mesospaced surface

Bong Jin Hong, Joon Won Park

Proceedings Volume 5593, Nanosensing: Materials and Devices; (2004) https://doi.org/10.1117/12.569677
Event: Optics East, 2004, Philadelphia, Pennsylvania, United States

Abstract

A dendron having nine carboxylic acid groups at the end of the branches and a protected amine at the apex was allowed to form a molecular layer on the aminosilylated surface through multipoint ionic attraction. It was found that a compact and smooth monolayer was obtained at appropriate condition. The film quality was maintained successfully after deprotecting CBZ group with trimethylsilyl iodide. The surface density of the primary amine after the deprotection was measured with fluorometry, and 0.1-0.2 amine group per 1 nm² was observed. This implies that the spacing between the amine functional groups is 24-34 Å in hexagonal close packing (hcp) model. In addition, DNA microarrays were fabricated successfully on the dendron-modified surface.

Citation Download Citation

Bong Jin Hong and Joon Won Park "DNA microarrays on a mesospaced surface", Proc. SPIE 5593, Nanosensing: Materials and Devices, (29 December 2004); https://doi.org/10.1117/12.569677

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