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29 December 2004 Long-circulating QD probes for in vivo tumor imaging
Xiaohu Gao, Shuming Nie
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Proceedings Volume 5593, Nanosensing: Materials and Devices; (2004) https://doi.org/10.1117/12.583226
Event: Optics East, 2004, Philadelphia, Pennsylvania, United States
Abstract
Biocompatible semiconductor quantum dot (QD) probes with extended plasma circulating times have been developed for cancer imaging in living animals. The structural design involves encapsulating luminescent QDs with a triblock copolymer, and linking this amphiphilic polymer to multiple poly(ethylene glycol) (PEG) molecules. In vitro histology and in vivo imaging studies indicate that the QD probes can be delivered to tumor sites by enhanced permeation and retention. Using both systemic injection of long-circulating QD probes and subcutaneous injection of QD-tagged microbeads, we have achieved sensitive and multicolor fluorescence imaging of cancer cells under in vivo conditions. These results raise new possibilities for ultrasensitive and multiplexed imaging of molecular targets in vivo.
© (2004) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
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Xiaohu Gao and Shuming Nie "Long-circulating QD probes for in vivo tumor imaging", Proc. SPIE 5593, Nanosensing: Materials and Devices, (29 December 2004); https://doi.org/10.1117/12.583226
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Cited by 3 scholarly publications.
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KEYWORDS
Tumors
In vivo imaging
Polymers
Luminescence
Quantum dots
Cancer
Molecules
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