Sequence-specific DNA sensing based on silicon nanowires

Zhiyong Li; Xuema Li; Theodore I. Kamins; Yong Chen; R. Stanley Williams

doi:10.1117/12.570817

29 December 2004 Sequence-specific DNA sensing based on silicon nanowires

Zhiyong Li, Xuema Li, Theodore I. Kamins, Yong Chen, R. Stanley Williams

Proceedings Volume 5593, Nanosensing: Materials and Devices; (2004) https://doi.org/10.1117/12.570817
Event: Optics East, 2004, Philadelphia, Pennsylvania, United States

Abstract

Highly sensitive, sequence-specific and label-free DNA sensors were demonstrated by monitoring the electronic conductance of silicon nanowires with chemically bonded single stranded (ss) DNA or peptide nucleic acid (PNA) probe molecules. For a 12-mer oligonucleotide, tens of pM of target ss-DNA in solution was recognized when the complementary DNA oligonucleotide probe was attached to the SiNW surfaces. In contrast, ss-DNA samples of 1000x concentration with single base mismatch only produce a weak signal due to nonspecific binding.

Citation Download Citation

Zhiyong Li, Xuema Li, Theodore I. Kamins, Yong Chen, and R. Stanley Williams "Sequence-specific DNA sensing based on silicon nanowires", Proc. SPIE 5593, Nanosensing: Materials and Devices, (29 December 2004); https://doi.org/10.1117/12.570817

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