Photodynamic destruction of <i>Porphyromonas gingivalis</i> induced by delta-aminolaevulinic acid

Aleksander Sieron; Andrzej Wiczkowski; Mariusz Adamek; Lucja Dyla; Sebastian Mazur; Beata Wierucka-Mlynarczyk

doi:10.1117/12.584427

10 September 2004 Photodynamic destruction of Porphyromonas gingivalis induced by delta-aminolaevulinic acid

Aleksander Sieron, Andrzej Wiczkowski, Mariusz Adamek, Lucja Dyla, Sebastian Mazur, Beata Wierucka-Mlynarczyk

Proceedings Volume 5610, Laser Florence 2003: A Window on the Laser Medicine World; (2004) https://doi.org/10.1117/12.584427
Event: Laser Florence 2003: A Window on the Laser Medicine World, 2003, Florence, Italy

Abstract

Photodynamic therapy (PDT) is one of a novel modalities which has recently been exploited to eradicate various microorganisms. In our study we have evaluated bactericidal efficacy of PDT in the presence of 5-δ aminolaevulinic acid (ALA). Porphyromonas gingivalis were incubated with increasing concentration of ALA and subsequently irradiated by progressive light doses. Complete killing effect was obtained for bacteria irradiated with 25J/cm² in ALA solution final concentration of 1mM, 5mM, 10mM. Statistical analysis has revealed ALA concentration to be a major factor responsible for eradication of bacteria. The latter may be attributable to the known ALA dark toxicity.

Citation Download Citation

Aleksander Sieron, Andrzej Wiczkowski, Mariusz Adamek, Lucja Dyla, Sebastian Mazur, and Beata Wierucka-Mlynarczyk "Photodynamic destruction of Porphyromonas gingivalis induced by delta-aminolaevulinic acid", Proc. SPIE 5610, Laser Florence 2003: A Window on the Laser Medicine World, (10 September 2004); https://doi.org/10.1117/12.584427

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