Novel fluorescence-based integrated sensor for chemical and biological agent detection

Greg Frye-Mason; Martin Leuschen; Lara Wald; Kateri Paul; Lawrence F. Hancock; Steve Fagan; Justin Krouse; Kira D. Hutchinson

doi:10.1117/12.581275

29 December 2004 Novel fluorescence-based integrated sensor for chemical and biological agent detection

Greg Frye-Mason, Martin Leuschen, Lara Wald, Kateri Paul, Lawrence F. Hancock, Steve Fagan, Justin Krouse, Kira D. Hutchinson

Author Affiliations +

Proceedings Volume 5617, Optically Based Biological and Chemical Sensing for Defence; (2004) https://doi.org/10.1117/12.581275
Event: European Symposium on Optics and Photonics for Defence and Security, 2004, London, United Kingdom

Abstract

There is a renewed interest in the development of chemical and biological agent sensors due to the increased threat of weapons deployment by terrorist organizations and rogue states. Optically based sensors address the needs of military and homeland security forces in that they are reliable, rapidly deployed, and can provide continuous monitoring with little to no operator involvement. Nomadics has developed optically based chemical weapons sensors that utilize reactive fluorescent chromophores initially developed by Professor Tim Swager at MIT. The chromophores provide unprecedented sensitivity and selectivity toward toxic industrial chemicals and certain chemical weapon agents. The selectivity is based upon the reactivity of the G-class nerve agents (phosphorylation of acetylcholinesterase enzyme) that makes them toxic. Because the sensor recognizes the reactivity of strong electrophiles and not molecular weight, chemical affinity or ionizability, our system detects a specific class of reactive agents and will be able to detect newly developed or modified agents that are not currently known. We have recently extended this work to pursue a combined chemical/biological agent sensor system incorporating technologies based upon novel deep ultraviolet (UV) light emitting diodes (LEDs) developed out of the DARPA Semiconductor UV Optical Sources (SUVOS) program.

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Greg Frye-Mason, Martin Leuschen, Lara Wald, Kateri Paul, Lawrence F. Hancock, Steve Fagan, Justin Krouse, and Kira D. Hutchinson "Novel fluorescence-based integrated sensor for chemical and biological agent detection", Proc. SPIE 5617, Optically Based Biological and Chemical Sensing for Defence, (29 December 2004); https://doi.org/10.1117/12.581275

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KEYWORDS

Sensors

Chromophores

Light emitting diodes

Nerve agents

Toxic industrial chemicals

Explosives

Blistering agents

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