Pulse modulation image sensors for on-chip bioimaging and biosensing applications

Takashi Tokuda; David C. Ng; Hideki Okamoto; Keiichiro Kagawa; Jun Ohta; Masahiro Nunoshita

doi:10.1117/12.588168

7 March 2005 Pulse modulation image sensors for on-chip bioimaging and biosensing applications

Takashi Tokuda, David C. Ng, Hideki Okamoto, Keiichiro Kagawa, Jun Ohta, Masahiro Nunoshita

Proceedings Volume 5677, Sensors and Camera Systems for Scientific and Industrial Applications VI; (2005) https://doi.org/10.1117/12.588168
Event: Electronic Imaging 2005, 2005, San Jose, California, United States

Abstract

Image sensors with pulse modulation measurement scheme are fabricated for bioimaging and biosensing ap-plications. We designed pulse modulation photosensors, a 64×64-pixels image sensor for in vitro bioimaging, and a 176×144-pixels (QCIF) image sensor for in vivo bioimaging. We demonstrated the feasibility of the pulse modulation measurement scheme for biosensing applications. We obtained a dynamic range of 120dB and minimum sensing intensity level of 2nW/cm². We also confirmed that 0.2% of intensity change is detectable at the minimum intensity region. An in vitro, on-chip imaging of a mouse hippocampus was successfully demonstrated. A sensor module for in vivo imaging is also developed.

Citation Download Citation

Takashi Tokuda, David C. Ng, Hideki Okamoto, Keiichiro Kagawa, Jun Ohta, and Masahiro Nunoshita "Pulse modulation image sensors for on-chip bioimaging and biosensing applications", Proc. SPIE 5677, Sensors and Camera Systems for Scientific and Industrial Applications VI, (7 March 2005); https://doi.org/10.1117/12.588168

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