The photodynamic detection of mucosal abnormality in oral cancer patients: a pilot study

Martin O'Dwyer; Graham Ogden; Stuart McLaren; Miles Padgett

doi:10.1117/12.590179

23 March 2005 The photodynamic detection of mucosal abnormality in oral cancer patients: a pilot study

Martin O'Dwyer, Graham Ogden, Stuart McLaren, Miles Padgett

Proceedings Volume 5691, Optical Fibers and Sensors for Medical Applications V; (2005) https://doi.org/10.1117/12.590179
Event: SPIE BiOS, 2005, San Jose, CA, United States

Abstract

Patients who have had one oral cancer are at increased risk of developing a semi-malignant tumour. The detecting of oral cancer is made difficult (and is often delayed) by the unknown appearance of the early oral lesion. A technique that could reliably detect early cancers would be useful to the oral and dental health specialist. One possible technique is the use of a photosensitiser that may be preferentially taken up by cancerous cells. 5-aminolaevulinic acid (ALA) is one such drug that is converted to Protoporphyrin IX (PpIX) and fluoresces at 636nm when illuminated with light of wavelength 405nm. It has been hypothesized that cell inclined towards malignant change would have a higher metabolic rate, and thus convert more ALA into its metabolite PpIX. These drugs can then be detected using a technique called Photodynamic detection, through the analysis of their fluorescence spectra. We describe a pilot study that used a compact spectroscopic instrument designed to excite and measure fluorescence in the oral cavity. Some Inter-subject variation in PpIX time course characteristics may be evident in our volunteers, as has been reported by other researchers. The obtained data would suggest that this instrument may be a valuable tool for detecting early oral cancers. However, further studies are required, not least to ensure that these data are due to detection of ALA metabolite in cancer and not some other systemic effect.

Citation Download Citation

Martin O'Dwyer, Graham Ogden, Stuart McLaren, and Miles Padgett "The photodynamic detection of mucosal abnormality in oral cancer patients: a pilot study", Proc. SPIE 5691, Optical Fibers and Sensors for Medical Applications V, (23 March 2005); https://doi.org/10.1117/12.590179

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
4 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Luminescence

Cancer

Control systems

Biopsy

Fluorescence spectroscopy

Tissues

Tongue

Show All Keywords

Keywords/Phrases

Search In:

Publication Years