Integrated photonic system for optical imaging and spectroscopy: non-invasive monitoring of brain tumor (glioblastoma) angiogenesis

Vishal Saxena; Jon F. Nielsen; Walter Laug; Marvin Nelson

doi:10.1117/12.588720

28 April 2005 Integrated photonic system for optical imaging and spectroscopy: non-invasive monitoring of brain tumor (glioblastoma) angiogenesis

Vishal Saxena, Jon F. Nielsen, Walter Laug, Marvin Nelson

Author Affiliations +

Proceedings Volume 5693, Optical Tomography and Spectroscopy of Tissue VI; (2005) https://doi.org/10.1117/12.588720
Event: SPIE BiOS, 2005, San Jose, CA, United States

Abstract

In this paper we describe a novel integrated photonic system that can be applied for optical imaging of intracranial brain tumor (Glioblastoma) angiogenesis in small animal model. A non-invasive multi-modality approach based on near infrared spectroscopy (NIRS) technique namely: Steady State Diffuse Optical Spectroscopy (DOS) along with Magnetic Resonance Imaging (MRI) technique is applied for monitoring the concentration of oxyhemoglobin, deoxyhemoglobin and water within tumor region and for studying the vascular status of tumor and the physiological changes that occur during brain tumor angiogenesis.

Citation Download Citation

Vishal Saxena, Jon F. Nielsen, Walter Laug, and Marvin Nelson "Integrated photonic system for optical imaging and spectroscopy: non-invasive monitoring of brain tumor (glioblastoma) angiogenesis", Proc. SPIE 5693, Optical Tomography and Spectroscopy of Tissue VI, (28 April 2005); https://doi.org/10.1117/12.588720

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