Microfabricated substrates for spectroscopy and separation

Jennifer L. Sample; Stergios J. Papadakis; Michael J. Fitch; Joseph A. Miragliotta

doi:10.1117/12.612071

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29 March 2005 Microfabricated substrates for spectroscopy and separation

Jennifer L. Sample, Stergios J. Papadakis, Michael J. Fitch, Joseph A. Miragliotta

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Proceedings Volume 5699, Imaging, Manipulation, and Analysis of Biomolecules and Cells: Fundamentals and Applications III; (2005) https://doi.org/10.1117/12.612071
Event: SPIE BiOS, 2005, San Jose, CA, United States

Abstract

In this paper, we report the preliminary results from a microfabricated substrate system that is amenable to both electromagnetic field-enhanced spectroscopy such as surface enhanced Raman scattering (SERS) and analyte separation and detection. Substrates consisting of arrays of gold post-like and pit-like features of varying pitch on gold substrates were fabricated by electron beam lithography. These substrates were characterized and tested for reproducible SERS activity, as well as evaluated for incorporation into a microfluidic system for separation and identification of components of complex matrices. Identification of analytes relevant to biodetection and biological screening is reported.

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Jennifer L. Sample, Stergios J. Papadakis, Michael J. Fitch, and Joseph A. Miragliotta "Microfabricated substrates for spectroscopy and separation", Proc. SPIE 5699, Imaging, Manipulation, and Analysis of Biomolecules and Cells: Fundamentals and Applications III, (29 March 2005); https://doi.org/10.1117/12.612071

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