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25 March 2005 Integrated detection of nanomagnetic bioassay labels
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Abstract
Spintronics detection technology can add significant functionality to bioassay detection systems and improve their precision. Photonic detection is presently the dominant technology in bioassay systems. Optical detectors on mechanical scanners are used to read the vast majority of commercially produced DNA chips. Introduction of these optical systems into non-laboratory applications is greatly impeded by the cost, size, and complexity of optical systems. Magnetics can help by providing detectors and actuators that are inherently rugged, small, and mass-manufacturable. Magnetic nanoparticles are used in many biochemical assays as labels for concentration, manipulation and, more recently, detection. Typically one attaches the magnetic particles to the biochemical species of interest (target) using a chemically specific binding interaction. Once bound, the labels enable the manipulation of the target species through the application of magnetic forces. Spintronic sensors, specifically Giant Magnetoresistive (GMR) and Spin Dependent Tunneling (SDT), sensors have been developed to detect and quantify labels in two main formats: flowing in a microfluidic channel, and immobilized labels on a chip surface.
© (2005) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Mark Tondra and Carl Smith "Integrated detection of nanomagnetic bioassay labels", Proc. SPIE 5732, Quantum Sensing and Nanophotonic Devices II, (25 March 2005); https://doi.org/10.1117/12.582682
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