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14 April 2005 Computational modeling of cerebral aneurysms in arterial networks reconstructed from multiple 3D rotational angiography images
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Previous patient-specific computational fluid dynamics (CFD) models of cerebral aneurysms constructed from 3D rotational angiography have been limited to aneurysms with a single route of blood flow. However, there are numerous aneurysms that accept blood flow from more than one avenue of flow such as aneurysms in the anterior communicating artery. Although the anatomy of these aneurysms could be visualized with other modalities such as CTA and MRA, cerebral rotational angiography has the highest resolution, and is therefore the preferred modality for vascular CFD modeling. The purpose of this paper is to present a novel methodology to construct personalized CFD models of cerebral aneurysms with multiple feeding vessels from multiple rotational angiography images. The methodology is illustrated with two examples: a model of an anterior communicating artery aneurysm constructed from bilateral rotational angiography images, and a model of the complete circle of Willis of a patient with five cerebral aneurysms. In addition, a sensitivity analysis of the intraaneurysmal flow patterns with respect to mean flow balance in the feeding vessels was performed. It was found that the flow patterns strongly depend on the geometry of the aneurysms and the connected vessels, but less on the changes in the flow balance. These types of models are important for studying the hemodynamics of cerebral aneurysms and further our understanding of the disease progression and rupture, as well as for simulating the effect of surgical and endovascular interventions.
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Marcelo A. Castro, Christopher M. Putman, and Juan R. Cebral "Computational modeling of cerebral aneurysms in arterial networks reconstructed from multiple 3D rotational angiography images", Proc. SPIE 5746, Medical Imaging 2005: Physiology, Function, and Structure from Medical Images, (14 April 2005);

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