Conducting polymer as smart interfaces for cultured neurons

Arti Ahluwalia; Ines Mauricio; Alberto Mazzoldi; Giorgio Serra; Francesca Bianchi

doi:10.1117/12.593732

6 May 2005 Conducting polymer as smart interfaces for cultured neurons

Arti Ahluwalia, Ines Mauricio, Alberto Mazzoldi, Giorgio Serra, Francesca Bianchi

Proceedings Volume 5759, Smart Structures and Materials 2005: Electroactive Polymer Actuators and Devices (EAPAD); (2005) https://doi.org/10.1117/12.593732
Event: SPIE Smart Structures and Materials + Nondestructive Evaluation and Health Monitoring, 2005, San Diego, California, United States

Abstract

This work is part of a research project aimed at realising conducting polymer matrices for interfacing with cultured neurons. The polymer matrix has a dual function, one as a medium for recording electrical activity; the other is chemical stimulation through the release of bioactive molecules. In this work we use poly-3-hexylthiophene as a conducting polymer matrix. To test the polymer’s ability to release molecules upon the application of a potential it was doped with glutamate (GA). GA is an important neurotransmitter, and its controlled release can be important in several medical and tissue engineering applications. Diffusional and controlled release of GA from the polymer were assessed. Biocompatibility of the samples was evaluated at each stage using neuroblastoma cell cultures.

Citation Download Citation

Arti Ahluwalia, Ines Mauricio, Alberto Mazzoldi, Giorgio Serra, and Francesca Bianchi "Conducting polymer as smart interfaces for cultured neurons", Proc. SPIE 5759, Smart Structures and Materials 2005: Electroactive Polymer Actuators and Devices (EAPAD), (6 May 2005); https://doi.org/10.1117/12.593732

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