Preliminary investigations in vitro optical clearing of rat skin using island damage method for accelerated delivery of index-matching agents

A. A. Gavrilova; D. Tabatadze; J. Childs; I. Yaroslavsky; G. Altshuler; A. B. Pravdin; V. V. Tuchin

doi:10.1117/12.634858

22 June 2005 Preliminary investigations in vitro optical clearing of rat skin using island damage method for accelerated delivery of index-matching agents

A. A. Gavrilova, D. Tabatadze, J. Childs, I. Yaroslavsky, G. Altshuler, A. B. Pravdin, V. V. Tuchin

Author Affiliations +

Proceedings Volume 5771, Saratov Fall Meeting 2004: Optical Technologies in Biophysics and Medicine VI; (2005) https://doi.org/10.1117/12.634858
Event: Saratov, Russia, 2004, Saratov, Russian Federation

Abstract

Strong light scattering in skin prevents precise targeting of optical energy in therapeutic and diagnostic applications. Optical immersion based on matching refractive mdcx of scattering centers with that of surrounding matter through introduction of an exogenous index-matching agent can alleviate the problem. However, slow diffusion of the index-matching agent through skin barrier makes practical implementation of this approach difficult. We propose a method of accelerating penetration of the index-matching compounds by enhancing skin permeability through creating a lattice of micro-zones (islets) of limited thermal damage in the stratum comeum. Two index-matching agents, glucose and glycerol, were tested. Glycerol used as index-matching agent gave noticeably better clearance then 40% glucose solution.

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A. A. Gavrilova, D. Tabatadze, J. Childs, I. Yaroslavsky, G. Altshuler, A. B. Pravdin, and V. V. Tuchin "Preliminary investigations in vitro optical clearing of rat skin using island damage method for accelerated delivery of index-matching agents", Proc. SPIE 5771, Saratov Fall Meeting 2004: Optical Technologies in Biophysics and Medicine VI, (22 June 2005); https://doi.org/10.1117/12.634858

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