Distribution of DNA fragment sizes after irradiation with heavy ions

Ewa Gudowska-Nowak; Katarzyna Psonka; Stephan Brons; Gisela Taucher-Scholz

doi:10.1117/12.611827

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23 May 2005 Distribution of DNA fragment sizes after irradiation with heavy ions

Ewa Gudowska-Nowak, Katarzyna Psonka, Stephan Brons, Gisela Taucher-Scholz

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Proceedings Volume 5841, Fluctuations and Noise in Biological, Biophysical, and Biomedical Systems III; (2005) https://doi.org/10.1117/12.611827
Event: SPIE Third International Symposium on Fluctuations and Noise, 2005, Austin, Texas, United States

Abstract

Ionizing radiation is responsible for production of double strand breaks (DSB) in a DNA structure. In contrast to sparsely ionizing radiation, densely ionizing radiation produces DSBs that are randomly distributed along the DNA molecule and can form clusters of various size. The paper discusses minimalistic models that describe observable pattern of distribution of fragment lengths in DNA segments irradiated with heavy ions and applies the formalism to interpret the recent experimental data collected by use of the atomic force microscope (AFM).

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Ewa Gudowska-Nowak, Katarzyna Psonka, Stephan Brons, and Gisela Taucher-Scholz "Distribution of DNA fragment sizes after irradiation with heavy ions", Proc. SPIE 5841, Fluctuations and Noise in Biological, Biophysical, and Biomedical Systems III, (23 May 2005); https://doi.org/10.1117/12.611827

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