The 3-D collagen structure of equine articular cartilage, characterized using variable-angle-of-incidence polarization-sensitive optical coherence tomography

Nadya Ugryumova; Sergei V. Gangnus; Stephen J. Matcher

doi:10.1117/12.632977

29 August 2005 The 3-D collagen structure of equine articular cartilage, characterized using variable-angle-of-incidence polarization-sensitive optical coherence tomography

Nadya Ugryumova, Sergei V. Gangnus, Stephen J. Matcher

Author Affiliations +

Proceedings Volume 5861, Optical Coherence Tomography and Coherence Techniques II; 58610J (2005) https://doi.org/10.1117/12.632977
Event: European Conferences on Biomedical Optics 2005, 2005, Munich, Germany

Abstract

Polarization-sensitive optical coherence tomography has been used to spatially map the birefringence of equine articular cartilage. Images obtained in the vicinity of visible osteoarthritic lesions display a characteristic disruption of the regular birefringence bands shown by normal cartilage. We also note that significant (e.g. ×2) variations in the apparent birefringence of samples taken from young (18 month) animals that otherwise appear visually homogeneous are found over spatial scales of a few millimeters. We suggest that whilst some of this variation may be due to changes in the intrinsic birefringence of the tissue, the 3-D orientation of the collagen fibers relative to the plane of the joint surface should also be taken into account. We propose a method based on multiple angles of illumination to determine the polar angle of the collagen fibers.

Citation Download Citation

Nadya Ugryumova, Sergei V. Gangnus, and Stephen J. Matcher "The 3-D collagen structure of equine articular cartilage, characterized using variable-angle-of-incidence polarization-sensitive optical coherence tomography", Proc. SPIE 5861, Optical Coherence Tomography and Coherence Techniques II, 58610J (29 August 2005); https://doi.org/10.1117/12.632977

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