Raman spectroscopy: development of clinical applications for breast cancer diagnosis

Maryann Fitzmaurice M.D.; Abigail A. Haka; Zoya Volynskaya; Jason T. Motz; Joseph A. Gardecki; Jon Nazemi; Nancy Wang; Nina Klein; Robert Shenk; Joan Woletz; David Hicks; Joseph P. Crowe; Ramachnadra R. Dasari; Michael S. Feld

doi:10.1117/12.633003

7 October 2005 Raman spectroscopy: development of clinical applications for breast cancer diagnosis

Maryann Fitzmaurice M.D., Abigail A. Haka, Zoya Volynskaya, Jason T. Motz, Joseph A. Gardecki, Jon Nazemi, Nancy Wang, Nina Klein, Robert Shenk, Joan Woletz, David Hicks, Joseph P. Crowe, Ramachnadra R. Dasari, Michael S. Feld

Author Affiliations +

Proceedings Volume 5862, Diagnostic Optical Spectroscopy in Biomedicine III; 586201 (2005) https://doi.org/10.1117/12.633003
Event: European Conferences on Biomedical Optics 2005, 2005, Munich, Germany

Abstract

Currently breast cancer diagnosis is made clinically through triple assessment: annual clinical breast examination, x-ray mammography or breast ultrasound imaging, and biopsy. The majority of women with suspicious breast lesions undergo either stereotactic (needle) or surgical (excisional) biopsy. Due to a high incidence of "false positives" at clinical breast diagnosis and "false negatives" at surgery, a large number of women undergo unnecessary and costly breast surgery. We describe our program of development of techniques and instrumentation for clinical application of NIR Raman spectroscopy for improved breast cancer diagnosis.

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Maryann Fitzmaurice M.D., Abigail A. Haka, Zoya Volynskaya, Jason T. Motz, Joseph A. Gardecki, Jon Nazemi, Nancy Wang, Nina Klein, Robert Shenk, Joan Woletz, David Hicks, Joseph P. Crowe, Ramachnadra R. Dasari, and Michael S. Feld "Raman spectroscopy: development of clinical applications for breast cancer diagnosis", Proc. SPIE 5862, Diagnostic Optical Spectroscopy in Biomedicine III, 586201 (7 October 2005); https://doi.org/10.1117/12.633003

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