Indocyanine green-laser thermolysis of acne vulgaris

Elina A. Genina; Alexey N. Bashkatov; Georgy V. Simonenko; Valery V. Tuchin; Ilya V. Yaroslavsky; Gregory B. Altshuler

doi:10.1117/12.633088

26 August 2005 Indocyanine green-laser thermolysis of acne vulgaris

Elina A. Genina, Alexey N. Bashkatov, Georgy V. Simonenko, Valery V. Tuchin, Ilya V. Yaroslavsky, Gregory B. Altshuler

Proceedings Volume 5863, Therapeutic Laser Applications and Laser-Tissue Interactions II; 58630L (2005) https://doi.org/10.1117/12.633088
Event: European Conferences on Biomedical Optics 2005, 2005, Munich, Germany

Abstract

The near-infrared (NIR) laser radiation due to its high penetration depth is widely used in phototherapy and photothermolysis. In application to skin appendages a high selectivity of laser treatment is needed to prevent light action on surrounding tissues. Indocyanine Green (ICG) dye may provide a high selectivity of treatment due to effective ICG uploading by a target and its narrow band of considerable absorption just at the wavelength of the NIR diode laser. The goal of this study is to demonstrate the efficacy of the NIR diode laser photothermolysis in combination with topical application of ICG suggested for treatment of acne vulgaris. Two volunteers with back-located acne were enrolled. Skin sites of subjects were stained by ICG and irradiated by NIR laser-diode light (803 or 809 nm). The individual acne lesions were photothermally treated at 18 W/cm² (803 nm, 0.5 sec) without skin surface cooling or at 200 W/cm² (809 nm, 0.5 sec) with cooling. The results of the observations during a month after the treatment have shown that ICG stained acne inflammatory elements were destructed for light exposures of 0.5 sec.

Citation Download Citation

Elina A. Genina, Alexey N. Bashkatov, Georgy V. Simonenko, Valery V. Tuchin, Ilya V. Yaroslavsky, and Gregory B. Altshuler "Indocyanine green-laser thermolysis of acne vulgaris", Proc. SPIE 5863, Therapeutic Laser Applications and Laser-Tissue Interactions II, 58630L (26 August 2005); https://doi.org/10.1117/12.633088

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