Experimental and clinical studies on transmyocardial laser revascularzation (TMLR)

Masayoshi Okada

doi:10.1117/12.639109

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11 September 2006 Experimental and clinical studies on transmyocardial laser revascularzation (TMLR)

Masayoshi Okada

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Proceedings Volume 5967, 2004 Shanghai International Conference on Laser Medicine and Surgery; 596709 (2006) https://doi.org/10.1117/12.639109
Event: 2004 Shanghai international Conference on Laser Medicine and Surgery, 2004, Shanghai, China

Abstract

The number of patients with coronary artery disease has been increasing in Japan and several kinds of treatments have been performed to reduce their cardiovascular diseases. In patients with small branches, or diffuse stenotic lesions of the coronary arteries, on whom coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) cannot be carried out, it has been hemodynamically demonstrated possible to supply arterial blood from the left ventricular cavity to the ischemic myocardium through laser channels. On the basis of excellent experimental studies using mongrel dogs, newly created laser channels 0.2 mm in diameter have been confirmed to be histologically patent even 3 years after transmyocardial revascularization(TMLR). Thus, this method could be applied as an alternative procedure of transmyocardial revascularization. First clinical procedure of TMLR alone was performed on 55 year-old male patient with severe angina pectoris who had undergone pericardiectomy 7 years ago. He had no candidate for percutaneous coronary intervention, or coronary artery bypass grafting, because his left venticle had severe adhesion to the left lung. Therefore, this method was finally carried out. He is getting well after this surgical intervention. This procedure should be recommended for the patient with end-stage coronary artery disease.

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Masayoshi Okada "Experimental and clinical studies on transmyocardial laser revascularzation (TMLR)", Proc. SPIE 5967, 2004 Shanghai International Conference on Laser Medicine and Surgery, 596709 (11 September 2006); https://doi.org/10.1117/12.639109

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