Amorphous silicon based direct x-ray conversion detector for protein structure analysis

Afrin Sultana; Arokia Nathan; J. A. Rowlands

doi:10.1117/12.629543

14 October 2005 Amorphous silicon based direct x-ray conversion detector for protein structure analysis

Afrin Sultana, Arokia Nathan, J. A. Rowlands

Proceedings Volume 5969, Photonic Applications in Biosensing and Imaging; 596928 (2005) https://doi.org/10.1117/12.629543
Event: Photonics North, 2005, Toronto, Canada

Abstract

Detailed knowledge of protein structure is vital to the understanding of numerous biological processes and to expedite advancements in pharmaceutical research. The atomic structure of protein can be determined by measuring the intensity of its X-ray diffraction pattern. The functional wavelength of X-ray for this purpose lies in the range of 0.01-1 nm. The diffraction pattern produced by X-ray of such wavelength can be read by a large area (~ 20 cm x 20 cm) detector. The detector should have good spatial resolution (FWHM ~ 2 pixels) to detect every Bragg peak in the pattern. In addition, a wide dynamic range (~10⁶) is desirable to accurately measure the intensity of Bragg peaks. Amorphous silicon (a-Si:H) based detector is a potential candidate to meet these requirements; in particular, it is attractive by virtue of its inexpensive manufacturing process and large area compatibility compared to the existing CCD and image plate based detection techniques. In this work, we investigate by modeling the feasibility of an a-Si:H based detector for the study of protein structure. The proposed detector employs amorphous selenium (a-Se) photoconductor layer to directly convert the incident X-ray to a charge image, which is then electronically read by an array of a-Si:H thin film transistors. The modeling results show that the detector reasonably satisfies the requirements for determination of protein.

Citation Download Citation

Afrin Sultana, Arokia Nathan, and J. A. Rowlands "Amorphous silicon based direct x-ray conversion detector for protein structure analysis", Proc. SPIE 5969, Photonic Applications in Biosensing and Imaging, 596928 (14 October 2005); https://doi.org/10.1117/12.629543

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
12 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Sensors

X-rays

Proteins

X-ray detectors

Signal detection

Photons

Crystals

Show All Keywords

Keywords/Phrases

Search In:

Publication Years