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11 November 2005 Amplified electrocatalysis at DNA-modified nanowires for ultrasensitive biosensing
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Proceedings Volume 6007, Smart Medical and Biomedical Sensor Technology III; 600705 (2005) https://doi.org/10.1117/12.630723
Event: Optics East 2005, 2005, Boston, MA, United States
Abstract
Three-dimensional gold nanowire ensembles (NEE) are a novel and useful platform for electrochemical DNA detection. Work performed in our laboratory using the three-dimensional nanostructures with an electrocatalytic reporter system has produced attomole sensitivity towards target DNA sequences. Large electrocatalytic signals observed at DNA-modified nanowires produce high signal-to-noise ratios, which is one factor that contributes to the improved sensitivity. DNA- modified nanostructures generate amplified electrocatalysis signals that are significantly larger than those observed at bulk gold surfaces, and our experiments indicate that the three-dimensional architectures of the nanowires facilitate the electrocatalytic reaction because of enhanced diffusion and accessibility occurring around these structures. The heightened sensitivity achieved indicates that the nanowire ensembles constitute a promising platform for ultrasensitive biosensors.
© (2005) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Melissa A. Lapierre-Devlin and Shana O. Kelley "Amplified electrocatalysis at DNA-modified nanowires for ultrasensitive biosensing", Proc. SPIE 6007, Smart Medical and Biomedical Sensor Technology III, 600705 (11 November 2005); https://doi.org/10.1117/12.630723
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