Ten-minute analysis of drugs and metabolites in saliva by surface-enhanced Raman spectroscopy

Chetan Shende; Frank Inscore; Paul Maksymiuk; Stuart Farquharson

doi:10.1117/12.633281

11 November 2005 Ten-minute analysis of drugs and metabolites in saliva by surface-enhanced Raman spectroscopy

Chetan Shende, Frank Inscore, Paul Maksymiuk, Stuart Farquharson

Proceedings Volume 6007, Smart Medical and Biomedical Sensor Technology III; 60070S (2005) https://doi.org/10.1117/12.633281
Event: Optics East 2005, 2005, Boston, MA, United States

Abstract

Rapid analysis of drugs in emergency room overdose patients is critical to selecting appropriate medical care. Saliva analysis has long been considered an attractive alternative to blood plasma analysis for this application. However, current clinical laboratory analysis methods involve extensive sample extraction followed by gas chromatography and mass spectrometry, and typically require as much as one hour to perform. In an effort to overcome this limitation we have been investigating metal-doped sol-gels to both separate drugs and their metabolites from saliva and generate surface-enhanced Raman spectra. We have incorporated the sol-gel in a disposable lab-on-a-chip format, and generally no more than a drop of sample is required. The detailed molecular vibrational information allows chemical identification, while the increase in Raman scattering by six orders of magnitude or more allows detection of microg/mL concentrations. Measurements of cocaine, its metabolite benzoylecgonine, and several barbiturates are presented.

Citation Download Citation

Chetan Shende, Frank Inscore, Paul Maksymiuk, and Stuart Farquharson "Ten-minute analysis of drugs and metabolites in saliva by surface-enhanced Raman spectroscopy", Proc. SPIE 6007, Smart Medical and Biomedical Sensor Technology III, 60070S (11 November 2005); https://doi.org/10.1117/12.633281

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