Chip-scale fluorescence sensors

Daniel A. Cohen; Hisashi Masui; Mathew Schmidt; Brendan Moran; Steven P. Denbaars

doi:10.1117/12.632493

17 November 2005 Chip-scale fluorescence sensors

Daniel A. Cohen, Hisashi Masui, Mathew Schmidt, Brendan Moran, Steven P. Denbaars

Proceedings Volume 6008, Nanosensing: Materials and Devices II; 60080R (2005) https://doi.org/10.1117/12.632493
Event: Optics East 2005, 2005, Boston, MA, United States

Abstract

We demonstrate an integrated fluorescence sensor chip consisting of an InGaN-GaN light emitting diode for fluorescence excitation, a bonded silicon junction photodiode for fluorescence detection, and a thin film filter for pump rejection and fluorescence selectivity. Evanescent field excitation at the LED surface is used to lessen the background due to stray pump light. The device is robust, and amenable to wafer-scale fabrication. Initial results with CdSe/ZnS quantum dot fluorophores yield a surface-bound sensitivity of 10 femtomoles, from which we predict a bulk fluid sensitivity of ~ 10 nanomolar for typical antibody-antigen assays.

Citation Download Citation

Daniel A. Cohen, Hisashi Masui, Mathew Schmidt, Brendan Moran, and Steven P. Denbaars "Chip-scale fluorescence sensors", Proc. SPIE 6008, Nanosensing: Materials and Devices II, 60080R (17 November 2005); https://doi.org/10.1117/12.632493

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