Spray pyrolysis synthesis of particles possessing magnetic and luminescent properties: Application of magnetic/luminescent particles in immunoassays

D. Dosev; M. Nichkova; R. K. Dumas; Kai Liu; I. M. Kennedy

doi:10.1117/12.638599

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19 January 2006 Spray pyrolysis synthesis of particles possessing magnetic and luminescent properties: application of magnetic/luminescent particles in immunoassays

D. Dosev, M. Nichkova, R. K. Dumas, Kai Liu, I. M. Kennedy

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Proceedings Volume 6036, BioMEMS and Nanotechnology II; 60360T (2006) https://doi.org/10.1117/12.638599
Event: Microelectronics, MEMS, and Nanotechnology, 2005, Brisbane, Australia

Abstract

Many types of fluorescent nanoparticles have been investigated as alternatives to conventional organic dyes in biochemistry. In addition, magnetic beads are another type of particle that have a long history of biological applications. In this work we apply flame spray pyrolysis in order to engineer a novel type of nanoparticle that has both luminescent and magnetic properties. The particles have magnetic cores of iron oxide doped with cobalt and neodymium and luminescent shells of europium-doped gadolinium oxide (Eu:Gd₂O₃). Measurements on a Vibrating Sample Magnetometer showed an overall paramagnetic response of these composite particles. Fluorescence spectroscopy showed spectra typical of the Eu ion in a Gd₂O₃ host; a narrow emission peak centered near 615 nm. Our synthesis method offers low-cost, high-rate synthesis allowing a wide range of biological applications of magnetic/fluorescent core/shell particles. We demonstrate an immunoassay using the magnetic and fluorescent properties of the particles for separation and detection purposes.

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D. Dosev, M. Nichkova, R. K. Dumas, Kai Liu, and I. M. Kennedy "Spray pyrolysis synthesis of particles possessing magnetic and luminescent properties: application of magnetic/luminescent particles in immunoassays", Proc. SPIE 6036, BioMEMS and Nanotechnology II, 60360T (19 January 2006); https://doi.org/10.1117/12.638599

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