Mauna Kea technologies’ F400 prototype: a new tool for in vivo microscopic imaging during endoscopy

B. Viellerobe; A. Osdoit; C. Cavé; F. Lacombe; S. Loiseau; B. Abrat

doi:10.1117/12.646625

23 February 2006 Mauna Kea technologies' F400 prototype: a new tool for in vivo microscopic imaging during endoscopy

B. Viellerobe, A. Osdoit, C. Cavé, F. Lacombe, S. Loiseau, B. Abrat

Proceedings Volume 6082, Endoscopic Microscopy; 60820C (2006) https://doi.org/10.1117/12.646625
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

The purpose of this paper is to demonstrate potential for high resolution fluorescence imaging during standard endoscopic procedures using a catheter-based confocal endoscope, compatible with standard video-endoscopes. The instrument, an F400 prototype from Mauna Kea Technologies (Paris, France), may function in various imaging modalities: auto-fluorescence or exogenous fluorescence using topical applications of fluorophores. The system is composed of a Laser Scanning Unit, a range of fibered objectives and a dedicated software, which makes it possible to obtain images at a rate of 12 frames per second. These images have a lateral resolution of 2.5 microns, an axial resolution of 15 microns, a field of view up to 600 microns x 500 microns and can be obtained at depths up to 100 microns. The miniaturized fibered probes offer unique access capabilities, specifically through the operating channel of an endoscope. So far, these studies have demonstrated the safety and efficacy of the F400 in allowing confocal laser imaging of the internal microstructure of tissues in the anatomical tract accessed by the endoscope, thanks to the miniaturization of the system. The device can be considered as a new tool towards "optical biopsies" and in vivo histology, leading to more physiologically relevant data and cost effective medicine.

Citation Download Citation

B. Viellerobe, A. Osdoit, C. Cavé, F. Lacombe, S. Loiseau, and B. Abrat "Mauna Kea technologies' F400 prototype: a new tool for in vivo microscopic imaging during endoscopy", Proc. SPIE 6082, Endoscopic Microscopy, 60820C (23 February 2006); https://doi.org/10.1117/12.646625

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available