Analyzing the origin of spontaneous synchronized burst in cultured neuronal networks on MEA

Chuanping Chen; Lin Chen; Yunsheng Lin; Shaoqun Zeng

doi:10.1117/12.647101

3 March 2006 Analyzing the origin of spontaneous synchronized burst in cultured neuronal networks on MEA

Chuanping Chen, Lin Chen, Yunsheng Lin, Shaoqun Zeng

Proceedings Volume 6085, Complex Dynamics and Fluctuations in Biomedical Photonics III; 60850F (2006) https://doi.org/10.1117/12.647101
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

Many mammalian neuronal networks, such as Central Nervous System (CNS), fire single spikes and complex spike burst. In fact, the conditions for triggering burst are not well understood. In the paper multi-electrode array (MEA) is used to record the spontaneous electrophysiology activity of cultured rat hippocampal neuronal networks for long-term. The transition from single spikes to burst is observed on networks that is cultured about 3 weeks and quickly fire before burst activity. The firing rate during burst is lower than that before burst, but the difference of inter spike intervals (ISIs) between the two firing patterns is not distinctness. Moreover, the electrical activities on neighboring electrodes show strong synchrony during burst activity. In a word, the generation of burst requires that network has a sufficient level of excitation as well as the balance by synaptic inhibition.

Citation Download Citation

Chuanping Chen, Lin Chen, Yunsheng Lin, and Shaoqun Zeng "Analyzing the origin of spontaneous synchronized burst in cultured neuronal networks on MEA", Proc. SPIE 6085, Complex Dynamics and Fluctuations in Biomedical Photonics III, 60850F (3 March 2006); https://doi.org/10.1117/12.647101

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