In vivo functional photoacoustic imaging of brain tumor vasculature

Jung-Taek Oh; Meng-Lin Li; Xueyi Xie; George Stoica; Lihong V. Wang

doi:10.1117/12.645391

6 March 2006 In vivo functional photoacoustic imaging of brain tumor vasculature

Jung-Taek Oh, Meng-Lin Li, Xueyi Xie, George Stoica, Lihong V. Wang

Proceedings Volume 6086, Photons Plus Ultrasound: Imaging and Sensing 2006: The Seventh Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics; 60860C (2006) https://doi.org/10.1117/12.645391
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

We present a study of the functional photoacoustic imaging of tumor hypoxia in mice in vivo. Based on spectroscopic photoacoustic tomography that detects the optical absorption of oxy- and deoxy-hemoglobins, the blood oxygen saturation and the vascularization of brain tumors were visualized. U87 glioblastoma tumor cells were inoculated intracranially at a 3-mm depth from the surface of the nude mouse head seven days before the experiment. Increased blood content and hypoxia inside the tumor vasculature were detected through the intact skin and skull. This technique will be useful for future studies on tumor metabolic activities in the brain and hypoxia-related therapeutic resistance.

Citation Download Citation

Jung-Taek Oh, Meng-Lin Li, Xueyi Xie, George Stoica, and Lihong V. Wang "In vivo functional photoacoustic imaging of brain tumor vasculature", Proc. SPIE 6086, Photons Plus Ultrasound: Imaging and Sensing 2006: The Seventh Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 60860C (6 March 2006); https://doi.org/10.1117/12.645391

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