Optical microsensor for continuous glucose measurements in interstitial fluid

Jonathon T. Olesberg; Chuanshun Cao; Jeffrey R. Yager; John P. Prineas; Chris Coretsopoulos; Mark A. Arnold; Linda J. Olafsen; Michael Santilli

doi:10.1117/12.646751

27 February 2006 Optical microsensor for continuous glucose measurements in interstitial fluid

Jonathon T. Olesberg, Chuanshun Cao, Jeffrey R. Yager, John P. Prineas, Chris Coretsopoulos, Mark A. Arnold, Linda J. Olafsen, Michael Santilli

Author Affiliations +

Proceedings Volume 6094, Optical Diagnostics and Sensing VI; 609403 (2006) https://doi.org/10.1117/12.646751
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

Tight control of blood glucose levels has been shown to dramatically reduce the long-term complications of diabetes. Current invasive technology for monitoring glucose levels is effective but underutilized by people with diabetes because of the pain of repeated finger-sticks, the inconvenience of handling samples of blood, and the cost of reagent strips. A continuous glucose sensor coupled with an insulin delivery system could provide closed-loop glucose control without the need for discrete sampling or user intervention. We describe an optical glucose microsensor based on absorption spectroscopy in interstitial fluid that can potentially be implanted to provide continuous glucose readings. Light from a GaInAsSb LED in the 2.2-2.4 μm wavelength range is passed through a sample of interstitial fluid and a linear variable filter before being detected by an uncooled, 32-element GaInAsSb detector array. Spectral resolution is provided by the linear variable filter, which has a 10 nm band pass and a center wavelength that varies from 2.18-2.38 μm (4600-4200 cm^-1) over the length of the detector array. The sensor assembly is a monolithic design requiring no coupling optics. In the present system, the LED running with 100 mA of drive current delivers 20 nW of power to each of the detector pixels, which have a noise-equivalent-power of 3 pW/Hz^1/2. This is sufficient to provide a signal-to-noise ratio of 4500 Hz^1/2 under detector-noise limited conditions. This signal-to-noise ratio corresponds to a spectral noise level less than 10 μAU for a five minute integration, which should be sufficient for sub-millimolar glucose detection.

Citation Download Citation

Jonathon T. Olesberg, Chuanshun Cao, Jeffrey R. Yager, John P. Prineas, Chris Coretsopoulos, Mark A. Arnold, Linda J. Olafsen, and Michael Santilli "Optical microsensor for continuous glucose measurements in interstitial fluid", Proc. SPIE 6094, Optical Diagnostics and Sensing VI, 609403 (27 February 2006); https://doi.org/10.1117/12.646751

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available