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10 February 2006 Molecular imaging of photodynamic therapy
Sung K. Chang, Divya Errabelli, Imran Rizvi, Nicolas Solban, Katherine O'Riordan, Tayyaba Hasan
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Proceedings Volume 6097, Optical Molecular Probes for Biomedical Applications; 609701 (2006) https://doi.org/10.1117/12.649844
Event: SPIE BiOS, 2006, San Jose, California, United States
Abstract
Recent advances in light sources, detectors and other optical imaging technologies coupled with the development of novel optical contrast agents have enabled real-time, high resolution, in vivo monitoring of molecular targets. Noninvasive monitoring of molecular targets is particularly relevant to photodynamic therapy (PDT), including the delivery of photosensitizer in the treatment site and monitoring of molecular and physiological changes following treatment. Our lab has developed optical imaging technologies to investigate these various aspects of photodynamic therapy (PDT). We used a laser scanning confocal microscope to monitor the pharmacokinetics of various photosensitizers in in vitro as well as ex vivo samples, and developed an intravital fluorescence microscope to monitor photosensitizer delivery in vivo in small animals. A molecular specific contrast agent that targets the vascular endothelial growth factor (VEGF) was developed to monitor the changes in the protein expression following PDT. We were then able to study the physiological changes due to post-treatment VEGF upregulation by quantifying vascular permeability with in vivo imaging.
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Sung K. Chang, Divya Errabelli, Imran Rizvi, Nicolas Solban, Katherine O'Riordan, and Tayyaba Hasan "Molecular imaging of photodynamic therapy", Proc. SPIE 6097, Optical Molecular Probes for Biomedical Applications, 609701 (10 February 2006); https://doi.org/10.1117/12.649844
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KEYWORDS
Photodynamic therapy
Picosecond phenomena
Luminescence
In vivo imaging
Tumors
Microscopes
Tissues
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