Sensitive plasmonic biosensor using gold nanoparticles on a nano fiber tip

Pei-Kuen Wei; Yu-Jen Chang; Chia-Wei Lee

doi:10.1117/12.642541

23 February 2006 Sensitive plasmonic biosensor using gold nanoparticles on a nano fiber tip

Pei-Kuen Wei, Yu-Jen Chang, Chia-Wei Lee

Proceedings Volume 6099, Plasmonics in Biology and Medicine III; 60990J (2006) https://doi.org/10.1117/12.642541
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

We propose a fiber-optic biosensor based on the generation of local surface plasmons (LSR) near a nano fiber tip. The nano-optical fiber biosensor was made by shaping the fiber to form a taper with a tip size less than 100nm. Gold nanoparticles with 12nm diameter were immobilized to the tapered fiber's tip by modifying tip surface with NH₂ groups. Most of light in the fiber tip is confined by the total internal reflection. It generates substantial evanescent wave near the tip and effectively excites LSR on the nanogolds. The evanescent wave excitation results in very low background light and high signal to noise ratio. Using this nanofiber sensor, we have achieved a sensitivity of reflective index unit, ~4800 (% RIU^-1) in the intensity measurement. Furthermore, the LSR is excited only near the tip region. It takes advantage of ultra small detection area. Only micro-liter sample solution is needed for the detection.

Citation Download Citation

Pei-Kuen Wei, Yu-Jen Chang, and Chia-Wei Lee "Sensitive plasmonic biosensor using gold nanoparticles on a nano fiber tip", Proc. SPIE 6099, Plasmonics in Biology and Medicine III, 60990J (23 February 2006); https://doi.org/10.1117/12.642541

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available